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Article

FOXO3 longevity genotype attenuates the impact of hypertension on cerebral microinfarct risk.

Journal of hypertension - 1 Mar 2024

Nakagawa Kazuma, Chen Randi, Ross G Webster, Donlon Timothy A, Allsopp Richard C, Willcox D Craig, Morris Brian J, Willcox Bradley J, Masaki Kamal H

Abstract excerpt

OBJECTIVE: The G -allele of FOXO3 SNP rs2802292 , which is associated with human resilience and longevity, has been shown to attenuate the impact of hypertension on the risk of intracerebral hemorrhage (ICH). We sought to determine whether the FOXO3 G -allele similarly attenuates the impact of hypertension on the risk of cerebral microinfarcts (CMI). METHODS: From a prospective population-based cohort of American...

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Identifiers

PMID: 38009316
DOI: 10.1097/HJH.0000000000003620
PMCID: PMC10873049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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