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Article

Incidence of Alzheimer's Disease in Men with Late-Life Hypertension Is Ameliorated by FOXO3 Longevity Genotype.

Journal of Alzheimer's disease : JAD - 1 Jan 2023

Chen Randi, Morris Brian J, Donlon Timothy A, Ross G Webster, Kallianpur Kalpana J, Allsopp Richard C, Nakagawa Kazuma, Willcox Bradley J, Masaki Kamal H

Abstract excerpt

BACKGROUND: It is well established that mid-life hypertension increases risk of dementia, whereas the association of late-life hypertension with dementia is unclear. OBJECTIVE: To determine whether FOXO3 longevity-associated genotype influences the association between late-life hypertension and incident dementia. METHODS: Subjects were 2,688 American men of Japanese ancestry (baseline age: 77.0±4.1 years, range...

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Identifiers

PMID: 37483002
DOI: 10.3233/JAD-230350
PMCID: PMC10578238

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