Article
Comparative expression analysis reveals lineage relationships between human and murine gliomas and a dominance of glial signatures during tumor propagation in vitro.
Cancer research - 15 Sept 2013
Henriquez Nico V, Forshew Tim, Tatevossian Ruth, Ellis Matthew, Richard-Loendt Angela, Rogers Hazel, Jacques Thomas S, Reitboeck Pablo Garcia, Pearce Kerra, Sheer Denise, Grundy Richard G, Brandner Sebastian
Abstract excerpt
Brain tumors are thought to originate from stem/progenitor cell populations that acquire specific genetic mutations. Although current preclinical models have relevance to human pathogenesis, most do not recapitulate the histogenesis of the human disease. Recently, a large series of human gliomas and medulloblastomas were analyzed for genetic signatures of prognosis and therapeutic response. Using a mouse model...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.