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Article

Histone-Mutant Glioma: Molecular Mechanisms, Preclinical Models, and Implications for Therapy.

International journal of molecular sciences - 29 Sept 2020

Graham Maya S, Mellinghoff Ingo K

Abstract excerpt

Pediatric high-grade glioma (pHGG) is the leading cause of cancer death in children. Despite histologic similarities, it has recently become apparent that this disease is molecularly distinct from its adult counterpart. Specific hallmark oncogenic histone mutations within pediatric malignant gliomas divide these tumors into subgroups with different neuroanatomic and chronologic predilections. In this review, we...

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Identifiers

PMID: 33003625
DOI: 10.3390/ijms21197193
PMCID: PMC7582376

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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