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Article

Single-cell dissection of the genotype-immunophenotype relationship in glioblastoma.

Brain : a journal of neurology - 3 Sept 2025

Soni Nishant, Rawat Kavita, Chen Zhihong, DiMauro Angela, Giotti Bruno, Hambardzumyan Dolores, Tsankov Alexander M

Abstract excerpt

Glioblastoma is the most aggressive and lethal adult brain tumour. The cellular heterogeneity within the tumour microenvironment plays a crucial role in the complexity of treatment and poor survival. Glioblastoma is typically classified into three molecular subtypes (classical, mesenchymal and proneural) associated with EGFR, NF1 and PDGFRA genetic drivers, respectively. Yet, the role of these driver mutations in...

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Source

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Identifiers

PMID: 40215269
DOI: 10.1093/brain/awaf129
PMCID: PMC12404732

Genes

NF1
PDGFB
EGFR
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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