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Article

Mouse Models of Pediatric Supratentorial High-grade Glioma Reveal How Cell-of-Origin Influences Tumor Development and Phenotype.

Cancer research - 1 Feb 2017

Sreedharan Smitha, Maturi Naga Prathyusha, Xie Yuan, Sundström Anders, Jarvius Malin, Libard Sylwia, Alafuzoff Irina, Weishaupt Holger, Fryknäs Mårten, Larsson Rolf, Swartling Fredrik J, Uhrbom Lene

Abstract excerpt

High-grade glioma (HGG) is a group of primary malignant brain tumors with dismal prognosis. Whereas adult HGG has been studied extensively, childhood HGG, a relatively rare disease, is less well-characterized. Here, we present two novel platelet-derived growth factor (PDGF)-driven mouse models of pediatric supratentorial HGG. Tumors developed from two different cells of origin reminiscent of neural stem cells...

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Identifiers

PMID: 28115362
DOI: 10.1158/0008-5472.CAN-16-2482

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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