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Article

Notch Signaling in Vascular Development

1 Apr 2003

Abstract excerpt

Notch signaling is an extremely conserved and widely used mechanism regulating cell fate in metazoans. Interaction of Notch receptors (Notch) with their ligands (Delta-like or Jagged) leads to cleavage of the Notch intracellular domain (NICD) that migrates into the nucleus. In the nucleus, NICD associates with a transcription factor, RBP-Jk. The NICD-RBP-Jk complex, in turn, upregulates expression of primary...

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PMID: 12615665
DOI: 10.1161/01.atv.0000060892.81529.8f

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