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MyD88-dependent TLR signaling oppositely regulates hematopoietic progenitor and stem cell formation in the embryo

19 Jan 2022

Abstract excerpt

Hemogenic endothelial (HE) cells in the dorsal aorta undergo an endothelial-to-hematopoietic transition (EHT) to form multipotent progenitors, lympho-myeloid biased progenitors (LMPs), pre-hematopoietic stem cells (pre-HSCs) and adult-repopulating HSCs. These briefly accumulate in intra-arterial hematopoietic clusters (IAHCs) before being released into the circulation. It is generally assumed that the number of...

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PMID: 35043940
DOI: 10.1242/dev.200025

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