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Article

An alternative NURF complex sustains acute myeloid leukemia by regulating the accessibility of insulator regions

21 Nov 2023

Abstract excerpt

Efficient treatment of acute myeloid leukemia (AML) patients remains a challenge despite recent therapeutic advances. Here, using a CRISPRi screen targeting chromatin factors, we identified the nucleosome-remodeling factor (NURF) subunit BPTF as an essential regulator of AML cell survival. We demonstrate that BPTF forms an alternative NURF chromatin remodeling complex with SMARCA5 and BAP18, which regulates the...

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PMID: 37987160
DOI: 10.15252/embj.2023114221

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