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Transcription factor networks in B-cell differentiation link development to acute lymphoid leukemia

19 May 2015

Abstract excerpt

B-lymphocyte development in the bone marrow is controlled by the coordinated action of transcription factors creating regulatory networks ensuring activation of the B-lymphoid program and silencing of alternative cell fates. This process is tightly connected to malignant transformation because B-lineage acute lymphoblastic leukemia cells display a pronounced block in differentiation resulting in the expansion of...

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PMID: 25990863
DOI: 10.1182/blood-2014-12-575688

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