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Epigenetic regulator genes direct lineage switching in MLL/AF4 leukemia

15 Jul 2022

Abstract excerpt

The fusion gene MLL/AF4 defines a high-risk subtype of pro-B acute lymphoblastic leukemia. Relapse can be associated with a lineage switch from acute lymphoblastic to acute myeloid leukemia, resulting in poor clinical outcomes caused by resistance to chemotherapies and immunotherapies. In this study, the myeloid relapses shared oncogene fusion breakpoints with their matched lymphoid presentations and originated...

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PMID: 35839448
DOI: 10.1182/blood.2021015036

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