Article

Systematic functional screening of chromatin factors identifies strong lineage and disease dependencies in normal and malignant haematopoiesis

2022-08-13

Abstract excerpt

Interactions between transcription factors (TF) and chromatin factors (CF) regulate gene expression programmes to determine cellular fate. However, unlike for TF, the exact role of CF in this process is poorly understood. Using haematopoiesis as a model system and utilising novel functional CRISPR screens ex vivo and in vivo , coupled with Perturb-Seq, CF binding and genome-wide chromatin accessibility in primar...

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Literature Corpus work: 43cf4061-5e5a-5752-8118-1d2d2f0995e3
DOI: 10.1101/2022.08.11.503571

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