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Article

Canonical BAF complex regulates the oncogenic program in human T-cell acute lymphoblastic leukemia

3 Nov 2023

Abstract excerpt

ABSTRACT: Acute leukemia cells require bone marrow microenvironments, known as niches, which provide leukemic cells with niche factors that are essential for leukemic cell survival and/or proliferation. However, it remains unclear how the dynamics of the leukemic cell-niche interaction are regulated. Using a genome-wide CRISPR screen, we discovered that canonical BRG1/BRM-associated factor (cBAF), a variant of...

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PMID: 37922452
DOI: 10.1182/blood.2023020857

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