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Article

Differential results of genetic risk scoring for multiple sclerosis in European and African American populations.

Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Oct 2025

Rivier Cyprien A, Xu Leqi, Clocchiatti-Tuozzo Santiago, Zhao Hongyu, Ohno-Machado Lucila, Hafler David A, Falcone Guido J, Longbrake Erin E

Abstract excerpt

BACKGROUND: Genetic risk scores (GRSs) for multiple sclerosis (MS) help identify high-risk individuals and stratify populations for clinical trials, but most are derived from European populations, raising questions about GRS accuracy in other ancestries. OBJECTIVES: We aimed to determine whether an MS GRS can stratify individuals of African and Latino/admixed ancestry and assess whether the JointPRS tool enhances...

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Identifiers

PMID: 40991630
DOI: 10.1177/13524585251377607
PMCID: PMC12633797

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