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Polygenic risk score prediction of multiple sclerosis in individuals of South Asian ancestry

22 Feb 2023

Abstract excerpt

Abstract Polygenic risk scores aggregate an individual’s burden of risk alleles to estimate the overall genetic risk for a specific trait or disease. Polygenic risk scores derived from genome-wide association studies of European populations perform poorly for other ancestral groups. Given the potential for future clinical utility, underperformance of polygenic risk scores in South Asian populations has the...

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PMID: 37006331
DOI: 10.1093/braincomms/fcad041

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