Article
Polygenic risk score association with multiple sclerosis susceptibility and phenotype in Europeans.
Brain : a journal of neurology - 13 Feb 2023
Shams Hengameh, Shao Xiaorong, Santaniello Adam, Kirkish Gina, Harroud Adil, Ma Qin, Isobe Noriko, Schaefer Catherine A, McCauley Jacob L, Cree Bruce A C, Didonna Alessandro, Baranzini Sergio E, Patsopoulos Nikolaos A, Hauser Stephen L, Barcellos Lisa F, Henry Roland G, Oksenberg Jorge R
Abstract excerpt
Polygenic inheritance plays a pivotal role in driving multiple sclerosis susceptibility, an inflammatory demyelinating disease of the CNS. We developed polygenic risk scores (PRS) of multiple sclerosis and assessed associations with both disease status and severity in cohorts of European descent. The largest genome-wide association dataset for multiple sclerosis to date (n = 41 505) was leveraged to generate PRS...
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