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A primate nigrostriatal atlas of neuronal vulnerability and resilience in a model of Parkinson’s disease

18 Nov 2023

Abstract excerpt

The degenerative process in Parkinson's disease (PD) causes a progressive loss of dopaminergic neurons (DaNs) in the nigrostriatal system. Resolving the differences in neuronal susceptibility warrants an amenable PD model that, in comparison to post-mortem human specimens, controls for environmental and genetic differences in PD pathogenesis. Here we generated high-quality profiles for 250,173 cells from the...

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PMID: 37980356
DOI: 10.1038/s41467-023-43213-2

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