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Article

Mutant p53 and ELK1 co-drive FRA-1 expression to induce metastasis in breast cancer.

FEBS letters - 1 Dec 2023

Hu Sike, Wang Manxue, Ji Ailing, Yang Jie, Gao Ruifang, Li Xia, Sun Lili, Wang Jing, Zhang Ying, Liu Hongbin

Abstract excerpt

Tumor-associated p53 mutations induce activities different from wild-type p53, thus causing loss of the protein's tumor inhibition function. The cells carrying p53 mutations have more aggressive characteristics related to invasion, metastasis, proliferation, and cell survival. By comparing the gene expression profiles of mutant p53 (mutp53) and mutp53 silenced cohorts, we found that FOS-related antigen-1 (FRA-1),...

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Share to Breast Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ets-Domain Protein Elk-1

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Share to Proto-Oncogene Proteins c-fos

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Source

Identifiers

PMID: 37971884
DOI: 10.1002/1873-3468.14774

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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