Article

MAP3K1/MAP2K4 Mutations Drive Breast Cancer Progression by Compensating TP53 Loss via JNK2-p53-FOSL1 Axis Inactivation

2025-08-11

Abstract excerpt

<title>Abstract</title> <p>Background Breast cancer (BRCA) pathogenesis involves somatic mutations in key oncogenes and tumor suppressor genes, but the full spectrum of driver mutations and their functional impact remains incompletely understood. This study aimed to identify novel BRCA-specific driver mutations and elucidate their role in tumor progression. Methods We performed integrative analysis of The Cancer...

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Literature Corpus work: 18cc0448-dcda-5e12-ba2b-d2bd35745391
DOI: 10.21203/rs.3.rs-7033784/v1

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MAP3K1/MAP2K4 Mutations Drive Breast Cancer Progression by Compensating TP53 Loss via JNK2-p53-FOSL1 Axis InactivationDOI 10.21203/rs.3.rs-7033784/v1Read

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