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Article

FRA-1 as a Regulator of EMT and Metastasis in Breast Cancer

5 May 2023

Abstract excerpt

Among FOS-related components of the dimeric AP-1 transcription factor, the oncoprotein FRA-1 (encoded by FOSL1) is a key regulator of invasion and metastasis. The well-established FRA-1 pro-invasive activity in breast cancer, in which FOSL1 is overexpressed in the TNBC (Triple Negative Breast Cancer)/basal subtypes, correlates with the FRA-1-dependent transcriptional regulation of EMT (Epithelial-to-Mesenchymal...

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Cancer Cells and Metastasis
Cancer Genomics and Diagnostics
Cancer-related Molecular Pathways

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37176013
DOI: 10.3390/ijms24098307

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