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Article

The activating transcription factor 3 protein suppresses the oncogenic function of mutant p53 proteins.

The Journal of biological chemistry - 28 Mar 2014

Wei Saisai, Wang Hongbo, Lu Chunwan, Malmut Sarah, Zhang Jianqiao, Ren Shumei, Yu Guohua, Wang Wei, Tang Dale D, Yan Chunhong

Abstract excerpt

Mutant p53 proteins (mutp53) often acquire oncogenic activities, conferring drug resistance and/or promoting cancer cell migration and invasion. Although it has been well established that such a gain of function is mainly achieved through interaction with transcriptional regulators, thereby modulating cancer-associated gene expression, how the mutp53 function is regulated remains elusive. Here we report that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24554706
DOI: 10.1074/jbc.M113.503755
PMCID: PMC3979409

Genes

ATF3
NFKB2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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