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Article

FOSL2 Positively Regulates TGF-β1 Signalling in Non-Small Cell Lung Cancer

6 Nov 2014

Abstract excerpt

Fos-related antigen 2 (FRA-2/FOSL2) belongs to the AP-1 transcription factor family. Although FOSL2 has been shown to be involved in diverse physiological and pathological processes, very little is known about the signalling pathways that regulate FOSL2 expression and the mechanisms of FOSL2 function. Here, we show that FOSL2 expression is regulated by TGF-β1 and that FOSL2 is required for TGF-β1-induced...

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PMID: 25375657
DOI: 10.1371/journal.pone.0112150

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