Article
p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progression
31 Oct 2018
Abstract excerpt
gene and microenvironmentally driven activation of hypoxia-inducible factor-1 (HIF-1) typically occur in later stages of tumorigenesis. An ongoing challenge is the identification of molecular determinants of advanced cancer pathogenesis to design alternative last-line therapeutic options. Here, we report that p53 mutants influence the tumor microenvironment by cooperating with HIF-1 to promote cancer progression....
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