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Article

Alternative methods for CYP2D6 phenotyping: comparison of dextromethorphan metabolic ratios from AUC, single point plasma, and urine.

International journal of clinical pharmacology and therapeutics - 1 May 2016

Chen Rui, Wang Haotian, Shi Jun, Hu Pei

Abstract excerpt

PURPOSE: CYP2D6 is a high polymorphic enzyme. Determining its phenotype before CYP2D6 substrate treatment can avoid dose-dependent adverse events or therapeutic failures. Alternative phenotyping methods of CYP2D6 were compared to aluate the appropriate and precise time points for phenotyping after single-dose and ultiple-dose of 30-mg controlled-release (CR) dextromethorphan (DM) and to explore the antimodes for...

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Identifiers

PMID: 26902503
DOI: 10.5414/CP202387

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