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Article

Pharmacometabolomic approach to predict QT prolongation in guinea pigs.

PloS one - 1 Jan 2013

Park Jeonghyeon, Noh Keumhan, Lee Hae Won, Lim Mi-sun, Seong Sook Jin, Seo Jeong Ju, Kim Eun-Jung, Kang Wonku, Yoon Young-Ran

Abstract excerpt

Drug-induced torsades de pointes (TdP), a life-threatening arrhythmia associated with prolongation of the QT interval, has been a significant reason for withdrawal of several medicines from the market. Prolongation of the QT interval is considered as the best biomarker for predicting the torsadog...

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Identifiers

PMID: 23593245
DOI: 10.1371/journal.pone.0060556
PMCID: PMC3617128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23593245-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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