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Article

Pharmacometabolomic approach to predict QT prolongation in guinea pigs.

PloS one - 1 Jan 2013

Park Jeonghyeon, Noh Keumhan, Lee Hae Won, Lim Mi-sun, Seong Sook Jin, Seo Jeong Ju, Kim Eun-Jung, Kang Wonku, Yoon Young-Ran

Abstract excerpt

Drug-induced torsades de pointes (TdP), a life-threatening arrhythmia associated with prolongation of the QT interval, has been a significant reason for withdrawal of several medicines from the market. Prolongation of the QT interval is considered as the best biomarker for predicting the torsadogenic risk of a new chemical entity. Because of the difficulty assessing the risk for TdP during drug development, we...

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Identifiers

PMID: 23593245
DOI: 10.1371/journal.pone.0060556
PMCID: PMC3617128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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