Article
Heterogeneity of cortical pTDP-43 inclusion morphologies in amyotrophic lateral sclerosis.
Acta neuropathologica communications - 13 Nov 2023
Tan Rachel H, McCann Heather, Shepherd Claire E, Pinkerton Monica, Mazumder Srestha, Devenney Emma M, Adler Gabrielle L, Rowe Dominic B, Kril Jillian, Halliday Glenda M, Kiernan Matthew C
Abstract excerpt
BACKGROUND: Despite the presence of significant cortical pTDP-43 inclusions of heterogeneous morphologies in patients diagnosed with amyotrophic lateral sclerosis (ALS), pathological subclassification is routinely performed in the minority of patients with concomitant frontotemporal dementia (FTD). OBJECTIVE: In order to improve current understanding of the presence and relevance of pathological pTDP-43 subtypes...
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