Article
Neuropathological background of phenotypical variability in frontotemporal dementia.
Acta neuropathologica - 1 Aug 2011
Josephs Keith A, Hodges John R, Snowden Julie S, Mackenzie Ian R, Neumann Manuela, Mann David M, Dickson Dennis W
Abstract excerpt
Frontotemporal lobar degeneration (FTLD) is the umbrella term encompassing a heterogeneous group of pathological disorders. With recent discoveries, the FTLDs have been show to classify nicely into three main groups based on the major protein deposited in the brain: FTLD-tau, FTLD-TDP and FTLD-FUS. These pathological groups, and their specific pathologies, underlie a number of well-defined clinical syndromes,...
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