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Article

Quantitative patterns of motor cortex proteinopathy across ALS genotypes.

Acta neuropathologica communications - 2 Jul 2020

Nolan Matthew, Scott Connor, Gamarallage Menuka Pallebage, Lunn Daniel, Carpenter Kilda, McDonough Elizabeth, Meyer Dan, Kaanumalle Sireesha, Santamaria-Pang Alberto, Turner Martin R, Talbot Kevin, Ansorge Olaf

Abstract excerpt

Degeneration of the primary motor cortex is a defining feature of amyotrophic lateral sclerosis (ALS), which is associated with the accumulation of microscopic protein aggregates in neurons and glia. However, little is known about the quantitative burden and pattern of motor cortex proteinopathies across ALS genotypes. We combined quantitative digital image analysis with multi-level generalized linear modelling...

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Source

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Identifiers

PMID: 32616036
DOI: 10.1186/s40478-020-00961-2
PMCID: PMC7331195

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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