Article
TDP-43 pathologic lesions and clinical phenotype in frontotemporal lobar degeneration with ubiquitin-positive inclusions.
Archives of neurology - 1 Oct 2007
Grossman Murray, Wood Elisabeth M, Moore Peachie, Neumann Manuela, Kwong Linda, Forman Mark S, Clark Christopher M, McCluskey Leo F, Miller Bruce L, Lee Virginia M-Y, Trojanowski John Q
Abstract excerpt
BACKGROUND: TDP-43 is a major ubiquitinated disease protein in the pathologic condition of frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U). OBJECTIVE: To investigate the demographic, clinical, and neuropsychological features associated with subtypes of FTLD-U with TDP-43 inclusions (FTLD-U/TDP-43). DESIGN: Retrospective clinical-pathologic study. SETTING: Academic medical center....
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