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Human virome profiling identified CMV as the major viral driver of a high accumulation of senescent CD8 + T cells in patients with advanced NSCLC

8 Nov 2023

Abstract excerpt

Circulating senescent CD8 + T (T 8 sen) cells are characterized by a lack of proliferative capacities but retain cytotoxic activity and have been associated to resistance to immunotherapy in patients with advanced non–small cell lung cancer (aNSCLC). We aimed to better characterize T 8 sen and to determine which factors were associated with their accumulation in patients with aNSCLC. Circulating T 8 sen cells...

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PMID: 37939189
DOI: 10.1126/sciadv.adh0708

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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