Article

Age and CMV are not associated with clinical or immunological response to immune checkpoint blockade

2026-08-06

Abstract excerpt

Ageing and cytomegalovirus (CMV) infection drive major alterations to T-cell immunity. Age is also associated with an increased risk of cancers including melanoma, which is treated with T-cell modifying immune checkpoint blockade (ICB). However, the extent to which age, CMV, and treatment-induced immune changes interact to shape clinical outcomes remains poorly understood. We investigated this through flow cytomet...

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Literature Corpus work: 8775c48d-8a60-56ba-a9a1-fde0c2f0f4c5
DOI: 10.64898/2026.08.04.26359748

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