Article

Emergence of a senescent and inflammatory pulmonary CD4 <sup>+</sup> T cell population prior to lung allograft failure

2023-12-20

Abstract excerpt

Lung transplantation is a life-saving therapy for end-stage pulmonary disease, but its long-term outlook is poor due to a high incidence of chronic lung allograft dysfunction (CLAD). CLAD results from alloimmune-mediated progressive fibrosis and culminates in death or the need for re-transplantation after a median of 6 years. Existing immunosuppression fails to prevent CLAD, suggesting the existence of alloimmune...

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Literature Corpus work: ead92c66-0eb5-5a7a-a3f4-0d11bc64b8cc
DOI: 10.1101/2023.12.19.572416

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