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Article

CD8+CD57+ T cells exhibit distinct features in human non-small cell lung cancer.

Journal for immunotherapy of cancer - 1 Jun 2020

Huang Bing, Liu Rong, Wang Peiliang, Yuan Zhiwei, Yang Jianjian, Xiong Hui, Zhang Ni, Huang Qi, Fu Xiangning, Sun Wei, Li Lequn

Abstract excerpt

BACKGROUND: The repetitive antigen stimulation during chronic infection often leads to the accumulation of CD8+CD57+ T cells. These cells express high levels of interferon-γ, granzyme B and perforin with elevated cytolytic effect, and are considered as the most potent cells for combating chronical viral infection. The status of CD8+CD57+ T cells in non-small cell lung cancer (NSCLC) has not been well defined....

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Identifiers

PMID: 32606053
DOI: 10.1136/jitc-2020-000639
PMCID: PMC7328901

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