Human Immunodeficiency Virus Impairs Immune Responses to Tumor Neoepitopes Without Altering Mutational Profiles in NSCLC.

doi:10.1016/j.jtho.2025.02.001

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Article

Human Immunodeficiency Virus Impairs Immune Responses to Tumor Neoepitopes Without Altering Mutational Profiles in NSCLC.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Jul 2025

Abbar Baptiste, Labreche Karim, Cadranel Jacques, Veyri Marianne, Morin Véronique, Thiam Fatou Seck, Desire Nathalie, Baron Marine, Guillerm Erell, Perrier Alexandre, Fallet Vincent, Maitre Thomas, Canellas Anthony, Tarantino Nadine, Mze Oulfata, Samri Assia, Dejancourt Lisa, Nakid-Cordero Cecilia, Vozy Aurore, Picca Alberto, Touat Mehdi, Guihot Amélie, Chouaid Christos, Mokhtari Karima, Bielle Franck, Brocheriou Isabelle, Rouvier Philippe, Osorio Anita Rodenas, Buob David, Bouzidi Amira, Marie Yannick, Assouad Jalal, Boelle Pierre-Yves, Coulet Florence, Vieillard Vincent, Spano Jean-Philippe, Autran Brigitte

Abstract excerpt

INTRODUCTION: NSCLC is frequent and associated with poor prognosis among people living with human immunodeficiency virus (PLWHIV); nevertheless, the contributing factors remain unknown. METHODS: We prospectively compared the immunogenomic characteristics of 27 NSCLC samples from 15 PLWHIV and 12 immunocompetent patients (ICs). Tumor whole-exome and RNA sequencing, along with a bioinformatics pipeline, allowed...

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PMID: 39923848
DOI: 10.1016/j.jtho.2025.02.001

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