Article

Metabolic predictors of response to immune checkpoint blockade therapy

2023-04-21

Abstract excerpt

Metabolism of immune cells in the tumor microenvironment (TME) plays a critical role in cancer patient response to immune checkpoint inhibitors (ICI). Yet, a metabolic characterization of immune cells in the TME of patients treated with ICI is lacking. To bridge this gap we performed a semi-supervised analysis of ∼1700 metabolic genes using single-cell RNA-seq data of >1 million immune cells from ∼230 tumor and bl...

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Literature Corpus work: 388b42e1-d88e-5829-a204-7fd64475f910
DOI: 10.1101/2023.04.21.537496

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