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Metabolic predictors of response to immune checkpoint blockade therapy

12 Oct 2023

Abstract excerpt

Metabolism of immune cells in the tumor microenvironment (TME) plays a critical role in cancer patient response to immune checkpoint inhibitors (ICI). Yet, a metabolic characterization of immune cells in the TME of patients treated with ICI is lacking. To bridge this gap we performed a semi-supervised analysis of ∼1700 metabolic genes using single-cell RNA-seq data of > 1 million immune cells from ∼230 samples of...

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PMID: 37965137
DOI: 10.1016/j.isci.2023.108188

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