Article
Isolation and Characterization of Monomeric Human RAD51: A Novel Tool for Investigating Homologous Recombination in Cancer.
Angewandte Chemie (International ed. in English) - 18 Dec 2023
Rinaldi Francesco, Schipani Fabrizio, Balboni Beatrice, Catalano Federico, Marotta Roberto, Myers Samuel H, Previtali Viola, Veronesi Marina, Scietti Luigi, Cecatiello Valentina, Pasqualato Sebastiano, Ortega Jose Antonio, Girotto Stefania, Cavalli Andrea
Abstract excerpt
DNA repair protein RAD51 is a key player in the homologous recombination pathway. Upon DNA damage, RAD51 is transported into the nucleus by BRCA2, where it can repair DNA double-strand breaks. Due to the structural complexity and dynamics, researchers have not yet clarified the mechanistic details of every step of RAD51 recruitment and DNA repair. RAD51 possesses an intrinsic tendency to form oligomeric...
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