Article
Mechanistic insights into RAD51-associated protein 1 (RAD51AP1) action in homologous DNA repair.
The Journal of biological chemistry - 6 Apr 2012
Dunlop Myun Hwa, Dray Eloïse, Zhao Weixing, San Filippo Joseph, Tsai Miaw-Sheue, Leung Stanley G, Schild David, Wiese Claudia, Sung Patrick
Abstract excerpt
Homologous recombination catalyzed by the RAD51 recombinase is essential for maintaining genome integrity upon the induction of DNA double strand breaks and other DNA lesions. By enhancing the recombinase activity of RAD51, RAD51AP1 (RAD51-associated protein 1) serves a key role in homologous recombination-mediated chromosome damage repair. We show here that RAD51AP1 harbors two distinct DNA binding domains that...
Topics
- Amino Acid Sequence
- Amino Acid Substitution
- Conserved Sequence
- DNA
- DNA Repair
- DNA-Binding Proteins
- HeLa Cells
- Humans
- Mutagenesis, Site-Directed
- Peptide Fragments