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Article

Insights into DNA recombination from the structure of a RAD51-BRCA2 complex.

Nature - 21 Nov 2002

Pellegrini Luca, Yu David S, Lo Thomas, Anand Shubha, Lee MiYoung, Blundell Tom L, Venkitaraman Ashok R

Abstract excerpt

The breast cancer susceptibility protein BRCA2 controls the function of RAD51, a recombinase enzyme, in pathways for DNA repair by homologous recombination. We report here the structure of a complex between an evolutionarily conserved sequence in BRCA2 (the BRC repeat) and the RecA-homology domain of RAD51. The BRC repeat mimics a motif in RAD51 that serves as an interface for oligomerization between individual...

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Share to Amino Acid Motifs
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Share to Conserved Sequence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12442171
DOI: 10.1038/nature01230

Genes

RAD51
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Insights into DNA recombination from the structure of a RAD51-BRCA2 complex.PMID 12442171Read ↗

Breaking new ground into RAD51–BRC repeats interplay in Homologous RecombinationSemantic proximity Read ↗

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A variant of the breast cancer type 2 susceptibility protein (BRC) repeat is essential for the RECQL5 helicase to interact with RAD51 recombinase for genome stabilization.Semantic proximity Read ↗

Contributions of the RAD51 N-terminal domain to BRCA2-RAD51 interaction.Semantic proximity Read ↗

BRCA2 C-terminal clamp restructures RAD51 dimers to bind B-DNA for replication fork stability.Semantic proximity Read ↗

DMC1 and RAD51 bind FxxA and FxPP motifs of BRCA2 via two separate interfacesSemantic proximity Read ↗

Purified human BRCA2 stimulates RAD51-mediated recombination.Semantic proximity Read ↗

Structure and function of the RAD51B–RAD51C–RAD51D–XRCC2 tumour suppressorSemantic proximity Read ↗

Structural basis for stabilisation of the RAD51 nucleoprotein filament by BRCA2Semantic proximity Read ↗

RAD51 and PALB2 in precision oncology: Clinical implications for HRD associated breast and ovarian cancers (Review)Semantic proximity Read ↗

Defects in recombination activity caused by somatic and germline mutations in the multimerization/BRCA2 binding region of human RAD51 protein.Semantic proximity Read ↗

Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1.Semantic proximity Read ↗

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