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The BRCA Tumor Suppressor Network in Chromosome Damage Repair by Homologous Recombination

27 Mar 2019

Abstract excerpt

genes predispose afflicted individuals to breast, ovarian, and other cancers. The BRCA-encoded products form complexes with other tumor suppressor proteins and with the recombinase enzyme RAD51 to mediate chromosome damage repair by homologous recombination and also to protect stressed DNA replication forks against spurious nucleolytic attrition. Understanding how the BRCA tumor suppressor network executes its...

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PMID: 30917004
DOI: 10.1146/annurev-biochem-013118-111058

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