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Variation in RAD51 details a hub of functions: opportunities to advance cancer diagnosis and therapy

2018-12-03

Abstract excerpt

Loss of genome stability is one of the hallmarks of the enabling characteristics of cancer development. Homologous recombination is a DNA repair process that often breaks down as a prelude to developing cancer. Conversely, homologous recombination can be the Achilles’ heel in common anti-cancer therapies, which are effective by inducing irreparable DNA damage. Here, we review recent structural and functional studi...

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Literature Corpus work
f2f41439-f2a9-5d23-9e6e-1a34b3840870
DOI
10.12688/f1000research.15650.2
Open publication

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Variation in RAD51 details a hub of functions: opportunities to advance cancer diagnosis and therapyDOI 10.12688/f1000research.15650.2
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