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Article

Causal association of epigenetic aging and osteoporosis: a bidirectional Mendelian randomization study.

BMC medical genomics - 2 Nov 2023

Liang Xinyu, Shi Wei, Zhang Xinglong, Pang Ran, Zhang Kai, Xu Qian, Xu Chunlei, Wan Xin, Cui Wenhao, Li Dong, Jiang Zhaohui, Liu Zhengxuan, Li Hui, Zhang Huafeng, Li Zhijun

Abstract excerpt

BACKGROUND: The relationship between aging and osteoporosis is well established. However, the relationship between the body's physiological age, i.e. epigenetic age, and osteoporosis is not known. Our goal is to analyze the bidirectional causal relationship between epigenetic clocks and osteoporosis using a bidirectional Mendelian randomization study. METHODS: We used SNPs closely associated with GrimAge, Hannum,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37919683
DOI: 10.1186/s12920-023-01708-3
PMCID: PMC10623745

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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