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Differential white blood cell count and epigenetic clocks: a bidirectional Mendelian randomization study

27 Aug 2024

Abstract excerpt

BACKGROUND: Human aging and white blood cell (WBC) count are complex traits influenced by multiple genetic factors. Predictors of chronological age have been developed using epigenetic clocks. However, the bidirectional causal effects between epigenetic clocks and WBC count have not been fully examined. METHODS: This study employed Mendelian randomization (MR) to analyze summary statistics from four epigenetic...

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PMID: 39192327
DOI: 10.1186/s13148-024-01717-8

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