Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Causality between heart failure and epigenetic age: a bidirectional Mendelian randomization study.

ESC heart failure - 1 Oct 2023

Zhang Fengjun, Deng Shanshan, Zhang Jing, Xu Wenchang, Xian Dexian, Wang Yuxuan, Zhao Qiong, Liu Yuan, Zhu Xiuli, Peng Min, Zhang Lin

Abstract excerpt

AIMS: Heart failure (HF) is a prevalent age-related cardiovascular disease with poor prognosis in the elderly population. This study aimed to establish the causal relationship between ageing and HF by conducting a bidirectional Mendelian randomization (MR) analysis on epigenetic age (a marker of ageing) and HF. METHODS AND RESULTS: Genome-wide association study data for epigenetic age (GrimAge, HorvathAge,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aging
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Heart Failure

Share to Mendelian Randomization Analysis

Share to Prognosis

Share to Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 37452462
DOI: 10.1002/ehf2.14446
PMCID: PMC10567637

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Causality between heart failure and epigenetic age: a bidirectional Mendelian randomization study.PMID 37452462Read ↗

Causal relationship from heart failure to kidney function and CKD: A bidirectional two-sample mendelian randomization studySemantic proximity Read ↗

Associations Between Vitamin D Levels and Risk of Heart Failure: A Bidirectional Mendelian Randomization StudySemantic proximity Read ↗

Causal effects between atrial fibrillation and heart failure: evidence from a bidirectional Mendelian randomization study.Semantic proximity Read ↗

Epigenetic age acceleration and risk of aortic valve stenosis: a bidirectional Mendelian randomization studySemantic proximity Read ↗

Causal Association Between Heart Failure and Alzheimer’s Disease: A Two-Sample Bidirectional Mendelian Randomization StudySemantic proximity Read ↗

Causal association between iron status and heart failure: A 2-sample bidirectional Mendelian randomization study.Semantic proximity Read ↗

Effects of COVID-19 on Heart Failure and Its Risk Factors: A Bidirectional Mendelian Randomization StudySemantic proximity Read ↗

Association of Epigenetic Age Acceleration with Early Stage Heart Failure: Sex-Specific Effects in the Project Baseline Health StudySemantic proximity Read ↗

Bidirectional 2-sample Mendelian randomization study of the causal relationship between hypothyroidism and cardiovascular diseases.Semantic proximity Read ↗

Causal association between heart failure and bone mineral density: Insights from a two-sample bidirectional Mendelian randomization study.Semantic proximity Read ↗

The bidirectional association between frailty index and cardiovascular disease: A Mendelian randomization study.Semantic proximity Read ↗

Accelerated electrocardiographic aging of the heart as a risk determinant for atrial fibrillation: A Mendelian randomization studySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.