Article
C3aR Antagonist Alleviates C3a Induced Tubular Profibrotic Phenotype Transition via Restoring PPARα/CPT-1α Mediated Mitochondrial Fatty Acid Oxidation in Renin-Dependent Hypertension.
Frontiers in bioscience (Landmark edition) - 17 Oct 2023
Wang Chongjian, Wang Zhiyu, Xu Jing, Ma Hongkun, Jin Kexin, Xu Tingting, Pan Xiaoxia, Feng Xiaobei, Zhang Wen
Abstract excerpt
BACKGROUND: Renin-dependent hypertension with tubulointerstitial injury remains a problem with high prevalence in the clinic. However, whether and how renin participates in tubulointerstitial injury remains incompletely understood. New evidence suggests that renin cleaves C3 into C3a and C3b. In the present study, we aimed to explore the role of renin-mediated C3a/C3a receptor (C3aR) signaling in renin-dependent...
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