Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A 3-hydroxy-3-methylglutaryl co-enzyme A reductase inhibitor reduces hypertensive nephrosclerosis in stroke-prone spontaneously hypertensive rats.

Journal of hypertension - 1 Dec 2002

Yamashita Tomoya, Kawashima Seinosuke, Miwa Yoichi, Ozaki Masanori, Namiki Masayuki, Hirase Tetsuaki, Inoue Nobutaka, Hirata Ken-ichi, Yokoyama Mitsuhiro

Abstract excerpt

BACKGROUND: Recent studies suggest that 3-hydroxy-3-methylglutaryl co-enzyme A reductase inhibitors (statins) exert their protective effects against cardiovascular diseases independently of their cholesterol-decreasing effects. OBJECTIVE: To clarify the effect of a statin on hypertensive nephrosclerosis. METHODS: We treated stroke-prone spontaneously hypertensive rats (spSHRs) chronically, starting at the age of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hydroxymethylglutaryl-CoA Reductase Inhibitors
Share to Lipids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proteinuria

Share to Rats, Inbred SHR

Share to Rats, Inbred WKY

Share to Stroke

Share to Transforming Growth Factor beta

Share to Transforming Growth Factor beta1

Source

Identifiers

PMID: 12473872
DOI: 10.1097/00004872-200212000-00027

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A 3-hydroxy-3-methylglutaryl co-enzyme A reductase inhibitor reduces hypertensive nephrosclerosis in stroke-prone spontaneously hypertensive rats.PMID 12473872Read ↗

Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors on renal function.Semantic proximity Read ↗

Nephroprotection by long-term ACE inhibition with ramipril in spontaneously hypertensive stroke prone rats.Semantic proximity Read ↗

Prevention of accelerated atherosclerosis by AT1 receptor blockade in experimental renal failure.Semantic proximity Read ↗

Statins and Cardiovascular Diseases: From Cholesterol Lowering to PleiotropySemantic proximity Read ↗

Amiloride reduces stroke and renalinjury in stroke-prone hypertensive rats.Semantic proximity Read ↗

Renal protective effect of TCV-116 in stroke-prone spontaneously hypertensive rats.Semantic proximity Read ↗

Atorvastatin causes depressor and sympatho-inhibitory effects with upregulation of nitric oxide synthases in stroke-prone spontaneously hypertensive rats.Semantic proximity Read ↗

C3aR Antagonist Alleviates C3a Induced Tubular Profibrotic Phenotype Transition via Restoring PPARα/CPT-1α Mediated Mitochondrial Fatty Acid Oxidation in Renin-Dependent Hypertension.Semantic proximity Read ↗

Protective effects of Rho kinase inhibitor fasudil on rats with chronic kidney disease.Semantic proximity Read ↗

Renoprotective Effects of Small Interfering RNA Targeting Liver Angiotensinogen in Experimental Chronic Kidney DiseaseSemantic proximity Read ↗

Transforming growth factor-beta expression in cardiovascular organs in stroke-prone spontaneously hypertensive rats with the development of hypertension.Semantic proximity Read ↗

Thromboxane A2 Receptor Antagonist (ONO-8809) Attenuates the Renal Disorders Caused by Salt-Overload in Stroke-Prone Spontaneously Hypertensive RatsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.