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Article

Structure-informed clustering for population stratification in association studies.

BMC bioinformatics - 31 Oct 2023

Bose Aritra, Burch Myson, Chowdhury Agniva, Paschou Peristera, Drineas Petros

Abstract excerpt

BACKGROUND: Identifying variants associated with complex traits is a challenging task in genetic association studies due to linkage disequilibrium (LD) between genetic variants and population stratification, unrelated to the disease risk. Existing methods of population structure correction use principal component analysis or linear mixed models with a random effect when modeling associations between a trait of...

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PMID: 37907836
DOI: 10.1186/s12859-023-05511-w
PMCID: PMC10619291

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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