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Article

A comparison of association methods correcting for population stratification in case-control studies.

Annals of human genetics - 1 May 2011

Wu Chengqing, DeWan Andrew, Hoh Josephine, Wang Zuoheng

Abstract excerpt

Population stratification is an important issue in case-control studies of disease-marker association. Failure to properly account for population structure can lead to spurious association or reduced power. In this article, we compare the performance of six methods correcting for population stratification in case-control association studies. These methods include genomic control (GC), EIGENSTRAT, principal...

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Identifiers

PMID: 21281271
DOI: 10.1111/j.1469-1809.2010.00639.x
PMCID: PMC3215268

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