A spectral component approach leveraging identity-by-descent graphs to address recent population structure in genomic analysis.

Abstract excerpt

Population structure is a well-known confounder in statistical genetics, particularly in genome-wide association studies (GWAS), in which it can lead to inflated test statistics and spurious associations. Traditional methods, such as principal components (PCs), commonly used to adjust for population structure, are limited in capturing fine-scale, nonlinear patterns that arise from recent demographic events,...

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