Article
Improved correction for population stratification in genome-wide association studies by identifying hidden population structures.
Genetic epidemiology - 1 Apr 2008
Li Qizhai, Yu Kai
Abstract excerpt
Hidden population substructure can cause population stratification and lead to false-positive findings in population-based genome-wide association (GWA) studies. Given a large panel of markers scanned in a GWA study, it becomes increasingly feasible to uncover the hidden population substructure within the study sample based on measured genotypes across the genome. Recognizing that population substructure can be...
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